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KMID : 0374019900130040285
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Ewha Medical Journal
1990 Volume.13 No. 4 p.285 ~ p.291
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Increased UDP-Glucuronosyltransferase Activity in the Liver of Butylated Hydroxyanisole and Butylated Hydroxytoluene-Treated Rats
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Abstract
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Butylated hydroxyanisole(BHA) has been shown to decrease the toxicological and carcinogenic potential of a variety of chemicals. One possible mechanism for chemoprotection is that BHA increases intestinal UDP-glucronosyltransferase activity and thereby enhances the elimination of the toxicants. Given that LP injection is a major route of xenobioctic exposure, we have investigated the action of BHA and BHT on glucuronidation capacity in the liver of rats. Simple injection of BHA(100mg/kg or 200mg/kg) and BHT(100mg/kg or 200mg/kg) produced a significant increase in microsomal glucuronidation. Futhermore, the concentration of UDP-glucuronic acid, the co-substrate required for glucuronidation reaction was increased almost 2-fold. Administration of BHA and BHT also increased UDP-glucose concentration and UDP-glucose dehydrogenase activities approximately 2-fold. These findings show that BHA and BHT administration increase hepatic glucuronidation capacity and suggest that BHA and BHT may enhance the biotransformation of xenobiotics, and hence excretion, of a variety of carcinogen and or toxins is potentially very important.
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KEYWORD
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